The Role of Wnt Signalling in the Development of Somites and Neural Crest
Advences in Anatomy, Embryology and Cell Biology
Corina Schmidt, Imelda McGonnell, Steve Allen, Ketan Patel (Nidottu, pehmeäkantinen)
Toimitusaika: 5-15 arkipäivää
The Wnt family of secreted signalling molecules controls a wide range of developmental processes in all metazoans. In this investigation, the authors have concentrated on the role that members of this family play during the development of the somites and the neural crest. Finally they have isolated a novel component of the Wnt signalling pathway called Naked Cuticle and investigated the role that this protein may play in both the previously mentioned processes. TOC:1. Introduction.- 1.1 Wnts and development.- 1.2. Somite formation.- 1.3. Induction, delamination and migration of neural crest.- 1.4. Outline of research plan.- 2. Material and methods.- 3. Results.- 3.1 Wnt6 and somitogenesis.- 3.2 The regulation of cNkd1 expression.- 3.3 Wnt6 and the neural crest.- 4. Discussion.- 5. Summary.- 7. References.- 8. Acknowledgements.- Subject index.
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